When PPG was assessed under conditions of standard meal and insulin administration in phase 2 and 3 studies of sotagliflozin in people with T1D, which represents the effects of sotagliflozin only on PPG, statistically significant and clinically meaningful reductions in PPG were indeed observed with sotagliflozin (17,28), consistent with the glucose absorption data presented here. This evidence concerns the gene INS and type 1 diabetes mellitus.