In addition, genetic partial loss of SGLT1 function is not only associated with lower PPG, but also with reduced rates of T2D, obesity, congestive heart failure and mortality in affected individuals, suggesting that partial pharmacologic inhibition of intestinal SGLT1 by sotagliflozin may provide similar beneficial effects (35). Here, SLC5A1 is linked to obesity due to melanocortin 4 receptor deficiency.