STAT3 and central nervous system cancer: Previous studies have demonstrated that IL‐6 recruits gp130 by binding to its receptor, the membrane‐bound IL‐6 receptor (mIL‐6R), to activate STAT3.36, 37, 38 Moreover, CD9 stabilizes gp130 to activate STAT3 in glioma stem cells by preventing its ubiquitin‐dependent lysosomal degradation.