ESR1 and metastasis: However, median survival time (MST, P = 0.006), age (P = 0.009), extra pleural metastasis (P = 0.040), WBC (P = 0.013), albumin (P = 0.006), CRP (P < 0.001), CYFRA (P = 0.431), ESR (P < 0.001), NLR (P < 0.001), PLR (P < 0.001), and LMR (P = 0.049) had significant differences among the three groups.