The abnormal synthesis of enzymes exists in the process of the transformation from normal to cancer cells and tumor proliferation.5 Some indicators routinely tested in clinical practice, such as alkaline phosphatase (ALP), adenosine deaminase (ADA)6 and lactate dehydrogenase (LDH)7 have been investigated to determine their prognostic values in various malignancies. The gene discussed is ADA; the disease is neoplasm.