The variables related with shorter survival time are listed as follows: small cell lung cancer (P = 0.037), WBC > 3.83 × 109/L (P = 0.003), neutrophil count (N) > 3.69 × 109/L (P < 0.001), monocyte count (M) > 0.37 × 109/L (P = 0.002), NLR > 4.17 (P = 0.001), LMR ≤ 5.71 (P = 0.013), fibrinogen >440.2 mg/dL (P = 0.042), ALP > 65 U/L (P = 0.009), CRP > 0.84 mg/dL (P = 0.001), ESR > 11 mm/hour (P = 0.016), CEA > 3.49 ng/mL (P = 0.010), NSE > 28.9 ng/mL (P < 0.001), pLDH > 155 U/L (P = 0.012), pleural effusion TP > 53 g/L (P = 0.003). The gene discussed is ENO2; the disease is Pleural effusion.