It has been shown to be involved in G2 arrest in oocytes and its activity is regulated by AKT phosphorylation.10 PKMYT1 localizes to the cytoplasm by binding to the cell division cycle 2 (CDC2)/cyclin B complex.11 Its proposed function is to phosphorylate the Thr14/Thr15 residue on CDC2, thus inhibiting CDC2 activity and preventing cell cycle from entering mitosis.12, 13 Since PKMYT1 and WEE1 safeguard the G2/M phase transition, inhibitors against PKMYT1 and WEE1 may effectively lower the survival ability of tumour cells and thus hold therapeutic potential for clinical use. The gene discussed is WEE1; the disease is neoplasm.