PKMYT1 and breast carcinoma: This study was the first to investigate the mRNA expression and prognosis of PKMYT1 in breast cancer, although other studies have reported PKMYT1 alternations in the occurrence and development of several cancers, including liver44 and colorectal carcinomas.45 As the key regulators of G2/M transition, WEE family kinases play essential role in maintaining cell genomic stability under rapid cell proliferation.