Taking lncRNA HOTAIR as an example, appraising its serum level seemed productive in diagnosing LSCC, with a high area under the receiver operating characteristic curve (AUC) value of 72.7%.6 Besides, artificially suppressing HOTAIR expression was discovered to curb in vitro metastasis of LSCC cells and excessive tumor growth in LSCC mice models,7 which insinuated HOTAIR as a potential target for LSCC treatment. Here, HOTAIR is linked to neoplasm.