The c‐statistic in the current study was larger than typically observed with CV prediction models for T2DM at 0.782, possibly explained by a diabetic cohort both with and without known cardiac conditions at baseline, and consideration of an endpoint more amenable to prediction (HF, rather than MI or ischemic stroke).20, 21 Not surprisingly, multiple CV‐related phenotypes (CAD, atrial fibrillation), traditional CV risk factors (age, systolic blood pressure, smoking), and markers of kidney dysfunction (blood urea nitrogen, albumin) were independent predictors of HHF. This evidence concerns the gene ALB and ischemic stroke.