We confirmed in OCI-Ly8 and Ramos cell xenograft models (to a lower extent) as well as in four human NHL biopsies the role of CDK1 phosphorylation at Tyr15 and Thr14 in G2/M cell cycle arrest and in cell death by using WEE-1 and MYT-1 inhibitors. This evidence concerns the gene CDK1 and non-Hodgkin lymphoma.