Table 3 further shows how cell cycle progression (as indicated by hepatic cyclin D1 gene expression) and tumour cell proliferation (as indexed by Ki67 immunolabelling) were strongly and significantly correlated with ECM production and tumour cell dissemination tendency (as assessed by the MMP-2:TIMP-1 ratio) (P < 0.001). The gene discussed is TIMP1; the disease is neoplasm.