MAPK3 and hepatocellular carcinoma: Furthermore, HCC model mice showed significantly higher p-ERK1/2:t-ERK1/2 ratios than normal mice (P < 0.001); however, treatment with SO, MBZ or a combination of both significantly decreased the ratio (P < 0.001 for SO or MBZ + SO, P < 0.01 for MBZ).