This is demonstrated in both the consistency of cut-offs for pTau and tTau, when derived from CSF samples collected from two different cohorts and analysed at different laboratories, and the ability of Tau/Aβ(1–42) ratios to accurately predict risk of cognitive decline in one cohort (ADNI) even when using cut-offs established in another cohort (BioFINDER). Here, MAPT is linked to Mental deterioration.