AD significantly dampened AR signalling; expression of AR target gene, kallikrein-3 (KLK3, encoding PSA)20 was significantly downregulated (p = 0.03; Fig. 2A), and PSA expression was undetectable after 15 days AD (Fig. 2B), whilst AR mRNA and protein expression remained evident throughout (Fig. 2A,B). This evidence concerns the gene AR and Alzheimer disease.