AR and prostate adenocarcinoma: Prostate adenocarcinoma rapidly acquires a NE-like phenotype and expresses NE markers under the potent selective pressure of androgen deprivation and AR inhibition (Figs. 1 and 2)31, highlighting the intrinsic capacity of the prostate epithelium to transdifferentiate into NE-cells and the central role of AR signalling in maintaining an epithelial phenotype.