AKT1 and ischemic stroke: Furthermore, a positive correlation was found between the core clock protein Bmal1 expression and neuronal survival, which were associated with the overactivation of survival kinases, such as phosphatidylinositol 3′-kinase/AKT (PI3K/AKT) and extracellular regulated kinase-1/2 (ERK-1/2) after ischemic stroke in mice11.