Notably, using the CSCO recommended thresholds of biomarkers instead of the critical cut-off values calculated by ROC analyses, the sensitivities of CEA, CA72-4 and CA19-9 in monitoring the therapeutic efficiencies of GC patients were even declined to 51.4%, 44.6%, and 34.9%, respectively (Supplemental Fig. S3). The gene discussed is CEACAM5; the disease is gastric cancer.