It appears that mice received S.obvelata like some nematodes can simulated tolerogenic-DCs (tDCs) and macrophages boosted Treg cells that secreted regulatory cytokines, such as IL-10 and TGF-β72,73, and inhibited the Th1- and Th17-related cytokines that leaded to attenuation of experimental colitis. Here, IL10 is linked to colitis.