Alzheimer’s Disease (AD) and vascular dementia (VaD), the second most common cause of dementia, are characterized by continual reduction in cognitive function and deterioration of memory, with the etiology likely due to environmental and genetic factors1, with the strongest genetic risk factor for AD being the ε4 variant of apolipoprotein E (ApoE). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.