OR2AG2 and asthma: Of the validated disease co-segregating genetic variants, one of the variants in gene OR2AG2 (c.161 G > C, rs10839616) belonging to the family of olfactory receptors, was chosen for further validation for three reasons: 1) it showed significant association with asthma in a small asthma case-control cohort from a different population signifying relevance in general population, 2) patients from the family self-reported inability to sense odors and fumes, and 3) the possibility of the gene’s novel role in asthma biology.