U2AF1 and metastatic neoplasm: To characterize the role of U2AF1 mutations, we collated sequencing data from a diverse set of 2112 LUADs, including cases from the original study identifying U2AF1 in LUAD20, The Cancer Genome Atlas33, metastatic tumors profiled with MSK-IMPACT42, tumors profiled as part of the TRACERx study43, and cases profiled using Stanford’s Solid Tumor Actionable Mutation Panel (STAMP)44.