CTSG and type 1 diabetes mellitus: Finally, to assess a potential relevance of miR142-3p inhibition in human T cells from an established T1D environment, we used peripheral blood mononuclear cells (PBMCs) from individuals with T1D for a pilot experiment to reconstitute the murine major histocompatibility complex II (MHCII) deficient, HLA-DQ8 transgenic NOD.Cg-PrkdcscidIl2rgtm1Wjl (NSG) mouse model7 for the establishment of humanized mice.