We confirmed the reduction in Tet2 abundance in CD4+T cells by immunofluorescence microscopy of pancreatic cryosections from NOD mice with or without IAA+ autoimmunity, which revealed significantly reduced numbers of pancreas-infiltrating CD3+Tet2+ T cells in IAA+ mice (Fig. 6b, c and Supplementary Fig. 13a) despite an increase in the total number of pancreas-infiltrating CD3+ T cells (Supplementary Fig. 13b). Here, CD4 is linked to Autoimmunity.