Next, to assess the relevance of miR142-3p activity for human Treg induction, we used naive CD4+ T cells (CD4+CD3+CD45RA+CD45RO−CD127+CD25−; Supplementary Fig. 4b) from individuals without islet autoimmunity, with recent onset of T1D, and with established T1D. This evidence concerns the gene CD4 and type 1 diabetes mellitus.