IDO2 and graft versus host disease: At the onset of acute GvHD, we observed a significant decrease in tryptophan metabolites, including microbiota-produced compounds, such as 3-indoxyl sulfate, indoleacetate, indoleacetylglutamine, and indolepropionate, and host-derived compounds produced by the IDO (indoleamine 2,3-dioxygenase) tolerogenic pathway37, N-acetylkynurenine and picolinic acid.