CD4 and infection: Moreover, our results are the first to show that levels of CXCL9 correlate negatively with CD4+ T-cell count at the 1-year-infection point and we speculate that this may be because, as CXCL9 levels are positively correlated with VL, and VL is negatively correlated with CD4+ T-cell count [46], CXCL9 may negatively influence CD4+ T-cell count.