APOC3 and coronary artery disorder: Consistently, in a cohort of 75,725 participants, the cumulative incidences of ischemic vascular disease and ischemic heart disease were reduced in heterozygotes for loss-of-function mutations in APOC3 (R19X or A43T or IVS2 + 1G → A) as compared with noncarriers, with corresponding risk reductions of 41% and 36% [4].