Food and Drug Administration (FDA) approved CTLA4 inhibitors such as ipilimumab, PD1 inhibitor nivolumab and PD-L1 inhibitor pembrolizumab in high mismatch repair-deficient high metastatic CRC [12], along with newly emerging drugs in combination with or without radiotherapy are just some of the ongoing clinical trials on CRC patients. This evidence concerns the gene PDCD1 and colorectal carcinoma.