An immune signature consisting of BCL3, CCL2, CCL3, CCL4L1, CCL4L2, CCL7, CD83, CTSL1, CXCL2, CXCL3, DEFA1, DUSP4, EREG, GNL1, GPR183, HBEGF, IL10, IL1R1, IL1R2, IL1RAP, IL6, IL8, IRS2, JUN, NFIL3, NFKBIA, NLRP3, OASL, OSM, PDCD1, PELI1, PIK3R1, PNP, PTGER4, RGCC, RGS1, RIPK2, SEMA7A, THBS1, TNFAIP3, ULBP2 and VEGFA, was enriched (p = 2.6 × 10−11) in PBMCs from CRC. The gene discussed is TNFAIP3; the disease is colorectal carcinoma.