Figure 8c depicts each of these transcripts and their heat maps in more detail including data from healthy donor PMBCs, CRC PBMCs, normal tissue and tumor tissue. Thirty six common downregulated transcripts between PBMCs and their matched CRC tumor tissues were detected (Figure 8d). Several upstream effectors were also commonly activated in both PBMC and TT (Figure 8b), these include FOXO1, BRD4 ERK1/2, JUN, NEDD9, STAT3, ERK, Jnk, TGFB1, with only one upstream effector inhibited found to be in common (COL18A1). The gene discussed is FOXO1; the disease is colorectal carcinoma.