An immune signature consisting of BCL3, CCL2, CCL3, CCL4L1, CCL4L2, CCL7, CD83, CTSL1, CXCL2, CXCL3, DEFA1, DUSP4, EREG, GNL1, GPR183, HBEGF, IL10, IL1R1, IL1R2, IL1RAP, IL6, IL8, IRS2, JUN, NFIL3, NFKBIA, NLRP3, OASL, OSM, PDCD1, PELI1, PIK3R1, PNP, PTGER4, RGCC, RGS1, RIPK2, SEMA7A, THBS1, TNFAIP3, ULBP2 and VEGFA, was enriched (p = 2.6 × 10−11) in PBMCs from CRC. Here, SEMA7A is linked to colorectal carcinoma.