TP53 and cancer: Figure S1a illustrates TP53 (tumor suppressor) at the center of the top predicted network (cancer, organismal injury and abnormalities and reproductive system disease) directly and indirectly activating 13 downstream effectors and suppressing 15 with varying intensities. The NFkB complex’s effect on cellular functionality, through IPA predictions is also illustrated (Figure S1b) with varying activation (red) and suppression (green) effects on molecules involved in cell to cell signaling, cellular movement and hematological system development and function.