HMGB1 and type 2 diabetes mellitus: Interestingly, a work by Hu and coworkers demonstrated that intravenous injection of bone marrow stromal cells into T2DM rats with experimental middle artery occlusion reduced HMGB1 and RAGE expression in ischemic brain, moreover it improved functional recovery and it attenuated blood brain barrier leakage by increasing levels of desmin and ZO-1 [92].