Schumacher et al. demonstrated that PGE2 exposure to human CRC cell lines promoted the dephosphorylation of cAMP response element-binding protein-regulated transcription co-activator 1 (CRTC1) to enhance CRTC1 transcriptional activity through EP1 and EP2 receptors signaling, resulting in the promotion of sporadic or colitis-associated colon cancer [34]. The gene discussed is CRTC1; the disease is malignant colon neoplasm.