NFKB1 and cancer: It has been shown that overexpression of N-cadherin induces anti-apoptosis pathway (or prevents apoptosis) in cancer cells through upregulation of decoy receptor DCR2, which plays an inhibitory role in apoptosis, a downregulation of death receptor DR5, which mediates apoptosis, and through the interference with MAPK/ERK and NF-kB/p65 signaling [29].