Indeed, the observation of TAM abundance and vasculature typical of myeloid cell proangiogenic activity in the context of the orthotopic CI-deficient xenografts corroborates our previous findings [3], suggesting that targeting CI in 143B osteosarcoma prevents HIF1-MIF activation, leading to TAM accumulation and vascular architecture remodeling. The gene discussed is MIF; the disease is osteosarcoma.