Similarly, co-delivery of wedelolatone (Wdl) and paclitaxel incorporated within PLGA NPs downregulated the ABCG2 and SOX-2 expression, sensitising tumour cells to paclitaxel treatment, and reducing the overall percentage of ALDH+ CSCs in vitro and in solid tumours [25]. Here, ABCG2 is linked to neoplasm.