In a model of hepatocellular carcinoma (HCC), HIF-1α upregulated the expression of chemokine (C-C motif) ligand 26 (CCL-26) in cancer cells, recruiting chemokine (C-X3-C motif) receptor 1 (CX3CR1) expressing-MDSCs to primary tumours and promoting HCC tumour growth. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.