For non-pCR patients—a clinically heterogenous population in terms of prognosis—there are few available therapeutic strategies (i.e., capecitabine in HER2-negative BC [25] and trastuzumab emtansine in HER2-positive BC [26]) that can be added to neoadjuvant therapy regimens to prevent recurrence. This evidence concerns the gene ERBB2 and breast cancer.