Through NGS methods, several lncRNAs have been identified as differentially expressed in RB and potent regulators of RB progression and metastasis, including BANCR, AFAP1-AS1, NEAT1, XIST, ANRIL, PlncRNA-1, HOTAIR, PANDAR, DANCR, and THOR [51]. The gene discussed is CDKN2B-AS1; the disease is retinoblastoma.