CCND1 and cancer: Consequently, the binding of mutant p53 R248Q to pSTAT3 prevents its dephosphorylation, leading to the hyperactivation of STAT3 signaling pathway that in turn drives cancer progression, by inducing the expression of target genes such as CCND1 (Cyclin D1), CCNB1 (Cyclin B1), and MYC (MYC Proto-Oncogene,) (Figure 2A).