TP53 and colorectal cancer: In a recent in vivo study of a mouse model of colorectal cancer (CRC), mutant p53 R248Q was shown to interact with phospho- Signal Transducer And Activator Of Transcription 3 (p-STAT3), to block its interaction with the tyrosine phosphatase SHP2 (Protein Tyrosine Phosphatase Non-Receptor Type 11).