TP53 and familial pancreatic carcinoma: In pancreatic cancer, mutant R172H p53 has been shown to interact with p73, blocking the interaction of p73 with NF-Y (nuclear transcription factor Y), which in turn induces the expression of PDGFRβ (platelet-derived growth factor receptor beta), which is important for maintaining a metastatic phenotype (Figure 2A) [91].