ACTA1 and Hepatic fibrosis: Furthermore, MSCsmiRNA-181-5p-Exos significantly down-regulated expression of pro-fibrotic genes (collagen I, vimentin, α-SMA and fibronectin) in HSCs, which led to the attenuation of CCl4-induced liver fibrosis in MSCsmiRNA-181-5p-Exos-treated mice [48].