We have observed that the RAS, including Ang II, is closely related with the 2k1c model [28] since their levels are elevated in the development and maintenance of hypertension in these animals: Early on, hypertension in 2k1c animals is characterized by increased plasma renin levels in response to low renal arterial pressure and subsequently by an increase in circulating Ang II. The gene discussed is REN; the disease is Hypertension.