A low-pH environment triggers the loss of E-cadherin expression in melanoma cells, and tumor cells primed at acidic pH have an increased adherence to the surface at normal pH in vitro and a higher metastatic potential in vivo [10,11], implicating the role of acidity in the migration of tumor cells from the original acidic tumor tissue to another non-tumor site. Here, CDH1 is linked to neoplasm.