Other immunological anomalies relevant to B cell autoreactivity in SLE include increased plasma cell differentiation and survival, upregulated Toll-like receptor (TLR) signaling and increased expression of key B cell cytokines such as BAFF, IL-6, and IL-21 [13,35,36,37,38,39,40]. The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.