Treatment of lupus prone NZB/W F1 mice with IL-6 exacerbated glomerulonephritis [46], whilst treatment with anti-IL-6 monoclonal antibodies in NZB/W F1 mice ameliorated kidney manifestations and reduced circulating anti-dsDNA autoantibodies titers [47,48]. The gene discussed is IL6; the disease is systemic lupus erythematosus.