The majority of desmin mutations result in cardiac manifestations, including conduction system defects and all forms of cardiomyopathy, with dilated cardiomyopathy (DCM) being the most frequent, followed by restrictive (RCM), hypertrophic (HCM), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and their combinations [19,20]. This evidence concerns the gene DES and familial dilated cardiomyopathy.