The majority of desmin mutations result in cardiac manifestations, including conduction system defects and all forms of cardiomyopathy, with dilated cardiomyopathy (DCM) being the most frequent, followed by restrictive (RCM), hypertrophic (HCM), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and their combinations [19,20]. Here, DES is linked to cardiomyopathy.