AKT1 and infection: Consequently, in the cells transfected with p38-MAPK specific siRNA, rAd-Rep2 infection-induced IL-10 production was markedly downregulated, whereas negative control siRNA (NC), Akt specific siRNA, and ERK specific siRNA transfection did not markedly change the IL-10 production in rAd-Rep2 infected-PAMs (Figure 3B).