Furthermore, as reported in another study, intraperitoneal (i.p.)injection of 11-cis-6-membered-ring-retinal to Abca4-/-Rdh8-/- mice that resemble many hallmarks of AMD and its juvenile form, Stargardt disease, prior to light illumination prevented the retinal degeneration in these mice. Here, RDH8 is linked to retinal degeneration.