RBM10 and thyroid gland undifferentiated (anaplastic) carcinoma: RBM10 was found to co-occur with NRAS. Other common mutations in fatal non-anaplastic thyroid cancer include mutations in genes involved in PI3K/AKT/PTEN/mTOR pathway, TP53, ATM, RB1, and POLE as well as genes involved in the chromatin remodeling complex and histone methyltransferases [97] (Figure 1) and 11% of PDTCs harbored EIF1AX mutations which were strongly associated with RAS.