The effect of methylation alterations in thyroid carcinogenesis is demonstrated by downregulation of several tumor suppressors thyroid cancer cells, such as; TSHR, PTEN, RASSF1A, CDKN2A, DAPK1, TIMP3, ECAD, and RAP1GAP [193,194,195,196,197,198]. The gene discussed is TIMP3; the disease is neoplasm.