The RET/PTC1 (CCDC6-RET) is the most common rearrangement, accounting for 60% of thyroid cancer with RET rearrangements, followed by RET/PTC3 (NCOA4-RET, 30%), and RET/PTC2 (PRKAR1A-RET, 5%). The gene discussed is RET; the disease is thyroid cancer.