PIK3CA and breast cancer: Early studies using inhibitors of PI3K (phosphoinositide 3-kinase) (e.g., copanlisib [11], buparlisib [12] or alpelisib [13]) or downstream mTOR (mammalian target of rapamycin) signaling complexes (e.g., temsirolimus [14,15] or everolimus [16,17]) in monotherapy indicate some clinical benefit in patients with advanced breast cancer.