In Sonic Hedgehog (SHH) MB, the crosstalk between basic fibroblast growth factor (bFGF/FGF2) activated fibroblast growth factor (FGF)-receptor (FGFR) and tumor growth factor receptor beta (TGF-β) signaling determines the migratory and the invasive capabilities of the tumor cells [3]. The gene discussed is FGF2; the disease is neoplasm.