On the other hand, these agents block the pro-angiogenic signaling pathways such as VEGF, PDGF, FGF, Ang, hematopoietic growth factor (HGF), IL-6 and so on, which regulate vessel permeability, remodeling, endothelial cell survival, proliferation and migration, leading to abnormal angiogenesis and tumor metastasis [90,91]. Here, VEGFA is linked to neoplasm.