CD4 and neoplasm: The percentage of tumor-infiltrating CD3+(n = 8/group; p < 0.001), CD4+ (p < 0.001), and CD8+ (p < 0.001) T cells was significantly reduced with increasing adiposity, as seen in Figure 5A. Increasing adiposity resulted in a significant increase in tumor-infiltrating Gr-1+CD11b+ MDSCs (p < 0.001), Gr-1HiCD11b+ gMDSCs 5B (p = 0.009) and Gr-1LoCD11b+ mMDSCs (p < 0.001), as seen in Figure 5B. Increased adiposity shifted the tumor-infiltrating gMDSC:mMDSC ratio to favor the presence of mMDSCs, as seen in Figure 4C (p < 0.001).