TFF3 and colorectal carcinoma: To determine the effects of TFF3 on CMS4 CRC progression, a forced expression model was established in Caco2 cells by stable transfection with TFF3 expression plasmid pIRESneo3-TFF3 (designated as Caco2-TFF3) or with empty vector pIRESneo3 (designated as Caco2-vec).