HIF-1α silencing is also effective to decrease invasive potential and rise chemosensitivity of human glioblastoma (LN229) and astrocytoma (U-251MG) cell lines to temozolomide [49], and to potentiate sorafenib-mediated apoptosis in HCC cells [50]. Here, HIF1A is linked to astrocytoma (excluding glioblastoma).