Zhao et al. [21] described that HIF-2α siRNA transfection downregulates TGF-α/EGFR pathway, promoting apoptosis in HCC models, while He et al. [36] observed that adriamycin-resistant ovarian cancer cells can be significantly sensitized by targeting breast cancer resistance protein (BCRP) expression. This evidence concerns the gene EGFR and ovarian carcinoma.