In most cases, 5-Aza was used to restore normal BNIP3 expression, sensitizing pancreatic cancer cells via hypoxia-mediated apoptosis promotion [13,15,18] and busulfan-resistant myeloid leukemia cells by upregulation of proapoptotic proteins, including BNIP3 [60]. Here, BNIP3 is linked to familial pancreatic carcinoma.