The study showed that IL-18 receptor−/− mice exhibit weight gain, ectopic lipid deposition, inflammation, and attenuated AMPK signaling in skeletal muscle, suggesting that IL-18 is involved in metabolic homeostasis, inflammation, and insulin resistance by activating the mechanism of adenosine monophosphate activated protein kinase (AMPK) in skeletal muscle [77]. The gene discussed is IL18; the disease is Insulin resistance.