In the adipose tissue of such individuals, especially in macrophages, the expression of the NLRP3 inflammasome components, the activity of caspase-1, and the level of IL-1β are increased, all of which are directly correlated with insulin resistance, metabolic syndrome, and the severity of T2DM [56,88]. The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.