The importance of NTE for neurobiology is emphasized by the observation that loss-of-function mutations in the human NTE/PNPLA6 gene are linked to several complex neurodegenerative syndromes, such as Motor neuron disease (MND), Hereditary Spastic Paraplegia 39 (SPG39), Boucher-Neuhäuser syndrome, Gordon-Holmes syndrome, cerebellar ataxia, Oliver-McFarlane syndrome and Laurence-Moon syndrome [16,17,18,19,20,21]. The gene discussed is PNPLA6; the disease is Trichomegaly - retina pigmentary degeneration - dwarfism.