SOCS3 and digestive system neoplasm: When GLP1 was administered (CD+GLP1+LT), it resulted in higher SOCS1 and SOCS3 expression than in the CD+LT group, and this was accompanied by less liver inflammation, evidenced by decreased levels of liver MPO, MDA, NO production, nitrotyrosine, and plasma vWF (Figure 5A,B).