In absence of p53 DPP4 moves from the nucleus to the cytoplasm where interacts with NADPH oxidase 1 (NOX1) triggering plasma membrane-associated lipid peroxidation that results in ferroptosis Interestingly, DPP4 depletion upregulates SLC7A11 expression in a p53-dependent manner suggesting a role of DPP4 in the control of SLC7A11 expression in TP53+ CRC cells [82]. This evidence concerns the gene NOX1 and colorectal carcinoma.