On the basis of tumor cell lines, the mechanisms of antiproliferative and pro-apoptotic activities of resveratrol have included: pro-oncogenic and tumor suppressor miRNAs expression modulation; NBkB, PPAR, PGC1α, NRF1,2, p53 transcription factors, and TGFβ signaling targeting pathways; prodifferentiating properties; and the synergistic effect of resveratrol on anticancer chemical drugs. This evidence concerns the gene TP53 and neoplasm.