The finding that 50μg/mL of PVP-GNPs induced toxic effects in tumour B16F10 cells but not PBMNCs, and induced proinflammatory cytokines’ response, especially, the induction of Th1 (IFN-γ and IL-12) response by PBMNCs, could be considered as beneficial for the development of anti-tumour therapy. This evidence concerns the gene IFNG and neoplasm.