IPA-derived relational networks reflect the possible roles of known oncogenes, e.g., MYC and HDGF (REF: PMID 27543492), overexpressed in B-raf V600E_high samples (Figure 6C), and tumor suppressors, e.g., PML and toll-like receptors (PMID: 30127747, 29416846), downregulated in B-raf V600E_high samples (Figure 6B). This evidence concerns the gene BRAF and neoplasm.